Associate Director, Automated High-throughput Production, Biologics Engineering, Oncology R&D
AstraZeneca

We are seeking an experienced scientist with significant automation and integration experience. The successful candidate will help build, shape and lead a team of scientist to improve and deliver on our High Throughput Production & Screening (HTPS) platform capabilities. You will play a significant role in designing future modifications to integrated robotic and liquid handling systems; ensuring world class precision and execution of high throughput expression & purification of antibody therapeutics on a microgram-to-milligram scale and be an advocate for utilizing various automation platforms. Furthermore you will manage and work side by side with the team. The selected individual will be a well-organized and a highly productive scientist that can design and execute experiments efficiently, as well as analyze, interpret, and present data to multidisciplinary project teams.

ABOUT ASTRAZENECA

At AstraZeneca, we put patients first and strive to meet their unmet needs worldwide. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality. If you are swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you're our kind of person.

SITE DESCRIPTION

Our Waltham, MA facility builds life-changing medicines for people around the world. The modern, vibrant scientific campus employs more than 800 experts in our field, and it is only a short drive from Boston, MA. With a shuttle bus to and from Alewife station, the location provides you the ability to work in the heart of one of the world's most vibrant research centers. It is filled with innovative technology. Our work areas were built to facilitate teamwork, interaction and cross functional science. We believe employees benefit from being challenged and inspired at work.

Our Waltham site offers a variety of amenities to help book productivity and help keep our employees happy and engaged. This includes a fitness center, employee healthcare clinic, electric vehicle charging stations, full-service cafeteria and copy center. This is where you'll find newly-designed, activity-based work spaces to suit a variety of working styles while increasing collaboration between teams and the greater research community. As AstraZeneca continues to put patients at the forefront of our mission, we are excited for our move to Kendall Square/Cambridge in 2026.

BUSINESS AREA

Biologics Engineering (BE) is large global organization with teams in Cambridge, UK and Gaithersburg MD responsible for the discovery and optimization of next generation biologics to create biological drug candidates for all key therapeutic areas such as oncology, respiratory and inflammation, cardiovascular, renal and metabolic diseases. Our Waltham team is a new team we are building from the ground up to support both our global responsibilities as well as building an innovation center where we can push the boundaries of sciences and creativity. We're constantly pushing the boundaries of science to deliver life-changing medicines to patients, with a passion for the development of in-house biologics discovery platforms and novel drug modalities to address unmet medical needs.

What you'll do

• Execute the set-up and integration of a complex multimillion dollar automation suite designed for high throughput DNA clone, transfection, expression, and purification on multiple scales.
  
• Collaborate and work with a diverse group of scientists across all therapeutic areas to ensure timely progress in research projects.
  
• Biochemical, biophysical and functional profiling of antibodies and recombinant antibody fragments.
  
• Ability to solve process development problems and implement improved procedures.
  
• Be a dynamic leader able to handle pressure while remaining confident.
  

Essential for the role

• Ph.D. in Biotechnology, Molecular Biology, Biochemistry or other relevant scientific field with 5+ years of experience in antibody engineering and/or bispecific design.
  
• OR MS Degree and 8+ years of experience in antibody engineering and/or bispecific design.
  
• OR BS Degree and 10+ years of experience in antibody engineering
  
• Line management and or laboratory management
  
• Molecular and cell biology techniques, including; cloning, transfection and transduction methods.
  
• Expression, purification and biochemical/biophysical characterization of various antibody formats.
  
• Optimizing/troubleshooting automation techniques (e.g. Hamilton liquid handler) with a problem-solving mindset.
  
• Sample tracking and laboratory logistics software.
  
• Ability to work independently, effectively plan and organize work activities and prioritize task completion to meet project deadlines.
  
• Track record of scientific innovation as evidenced by scientific publications, patents, and oral presentations at conferences.
  

Desirable for the role

• Antibody discovery using several cloning and purification technologies.
  
• Imaging/ multicolor flow cytometry-based instruments and data analysis programs.
  
• Tissue culture techniques and functional cell-based assay development.
  
• Effective presentation of complex scientific data to cross-functional and senior management.
  

Competitive salary & benefits

Close date: 23/04/2023

Why AstraZeneca?

At AstraZeneca when we see an opportunity for change, we seize it and make it happen, because any opportunity no matter how small, can be the start of something big.

So, what's next!

• Are you already imagining yourself joining our team? Good, because we can't wait to hear from you.
  

Where can I find out more?

Our Social Media, Follow AstraZeneca on LinkedIn: https://www.linkedin.com/company/1603/

Inclusion & Diversity: https://careers.astrazeneca.com/inclusion-diversity

Career Site: https://careers.astrazeneca.com/

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.

AstraZeneca requires all US employees to be fully vaccinated for COVID-19 but will consider requests for reasonable accommodations as required by applicable law.

This job has expired.