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Posted Job TitleResearch Specialist B (Department of Pulmonary, Allergy and Critical Care)Job Profile TitleResearch Specialist BJob Description SummaryThis Research Specialist position will work on testing the therapeutic efficacy of nanotechnologies for the treatment of acute brain pathologies, including ischemic stroke, traumatic brain injury, brain hemorrhagic stroke, and etc. Acute brain pathologies affect over one million Americans each year. There are several challenges to delivering therapeutics to the injured brain. Our lab packages drugs and gene therapy constructs (RNA) into nano-scale carriers (~100 nanometers in diameter), and targets them to the organ and cell types of interest using affinity moieties (e.g., antibodies), cell-hitchhiking, and medical devices. We tested these in mouse models of acute brain disorders, and are moving on to large animal models. We have close collaboration with the Neurology Department at the University of Pennsylvania. We also partner with existing companies and spin out our own start-ups, giving the opportunity to gain experience interacting with industry. The Research Specialist B will perform a broad range of experiments in pharmacology and mouse work. The methods will include animal model development and characterization (animal handling and surgery), pharmacological biodistribution experiments (injecting mice with drugs and harvesting organs to determine drug distribution), therapeutic safety and efficacy assessment (behavior, histology, safety assays, etc). (S)He will also prepare targeted nanocarriers a 10% of the time. The Principal Investigators and current lab personnel will design experiments with the applicant, but the Research Specialist will be expected to troubleshoot these procedures as needed. The Research Specialist will also keep accurate notebooks, perform data analysis, and assist in publication preparation.Job DescriptionJob Responsibilities
Production of drug-loaded nanocarriers
Mouse models of neurovascular inflammation such as stroke, TBI, etc followed by organ harvest, histology preparation and analysis, preparation of flow cytometry of single cells suspensions
Pharmacological biodistribution experiments (injecting mice with drugs and harvesting organs to determine drug distribution)
Presentations of data (during one-on-one meetings with adviser and during lab meeting)
Perform additional duties as assigned
Qualifications
About the Principal Investigators:
There are 3 co-advisors for this joint program: Oscar Marcos-Contreras is an assistant professor at Penn, where he develops nanomedicine for acute neuro-vascular injuries and inflammation. The lab technician will directly report to Oscar. Vladimir Muzykantov, MD, PhD is a professor at the University of Pennsylvania in the department of pharmacology, with decades of experience on vascular targeting using engineered proteins and nanomedicine. Jake Brenner, MD, PhD is an assistant professor and attending at the University of Pennsylvania. His nanomedicine lab is developing nanomedicine for acute critical illnesses, such as ARDS, sepsis, and stroke.
The Principal Investigator and senior personnel in the lab primarily design the experiments, but the applicant will be expected to troubleshoot these procedures as needed. The applicant will also keep accurate notebooks, perform data analysis, and assist in publication preparation. Additional duties will include assisting in experimental design, and participating in general laboratory activities such as lab meetings, ordering, and maintenance.
Job Location - City, StatePhiladelphia, PennsylvaniaDepartment / SchoolPerelman School of MedicinePay Range$37,220.00 - $57,335.40 Annual RateSalary offers are made based on the candidate's qualifications, experience, skills, and education as they directly relate to the requirements of the position, as well as internal and market factors and grade profile. Affirmative Action Statement
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