Senior Scientist - Antibody-Drug Conjugate Portfolio
AstraZeneca

Senior Scientist - Antibody-Drug Conjugate Portfolio

Are you ready to make a significant impact in the field of cancer biology? We are seeking a highly motivated and independent Senior Scientist to join our antibody-drug conjugates (ADCs) portfolio team within the Early Oncology Discovery group in Gaithersburg, MD USA. This is your chance to be a key member of a team focused on bringing new ADC projects into the portfolio and advancing them through all stages of pre-clinical development.

Accountabilities:

As a Senior Scientist, you will be expected to serve as Oncology biology lead for one or more pipeline programs, working collaboratively with cross-functional teams to ensure the timely generation and dissemination of critical program data. You will also be responsible for the delivery of key pre-clinical data that support a strong biological rationale for program progression. In addition, you will develop, design, conduct, troubleshoot, and analyze in vitro experiments to assess the function of our ADCs and dissect the mechanism of action of these novel cancer therapeutics.

Essential Skills/Experience:

• PhD Degree with 3+ years of experience, Master's Degree with 5+ years of experience, or a Bachelor's degree with 10+ years and project leadership experience in a relevant discipline.

• Demonstrated ability to lead cross functional project teams.

• Good knowledge of antibody-drug conjugates including bioassays to characterize them.

• Strong knowledge of cell biology, molecular biology, and/or biochemistry in the context of cancer biology.

• Experience cell-based methodologies such as multicolor flow cytometry, fluorescent and live cell microscopy, cytotoxicity assays especially in 3D are a must.

• Works independently to design and conduct key experiments to support program progression.

• Excellent communication, presentation, and interpersonal skills.

• A proven track record of productivity, as demonstrated by scientific publications in high quality peer-reviewed journals.

• Ensures own work, and work of peers, is compliant with Good Laboratory Practice, Safety, Health, and Environment standards and all other relevant internal AstraZeneca standards and external regulations.

Desirable Skills/Experience:

• Prior experience in the biopharmaceutical industry preferable but not required.

• Hands on experience with pre-clinical in vivo models of cancer would be viewed favorably.

• Experience in pre-clinical models of hematological cancer, and hematological cancer cell biology would be viewed favorably but not required.

When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.

Why AstraZeneca?

At AstraZeneca's Oncology R&D division, we push the boundaries of science to change the practice of medicine and transform the lives of patients living with cancer. We are a science-based, leading and decisive Oncology enterprise united in our vision to eliminate cancer as a cause of death. With one of the broadest and deepest Oncology pipelines in the industry, there are many opportunities to work with new and novel drugs and help discover what's next. We foster an attitude of courage, where everyone is empowered to step up, innovate and work at pace. Our pipeline is a testament to our growth, both now and in the future.

Are you ready to take a crucial inter-disciplinary approach to save patients' lives? Work at the forefront by taking an inter-disciplinary approach including novel biomarkers, AI, novel endpoints and ground breaking trial designs. It's because we are constantly innovating that we are able to develop life-changing medicines, change the way cancer is treated and ultimately improve outcomes for patients everywhere.

Ready to make your mark? Apply now and join us in our mission to eliminate cancer as a cause of death!

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.

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