Senior Scientist: ELISA, PCR, Cell Culture - Labs FSP
Thermo Fisher Scientific

Job Description

Thermo Fisher's clinical research business is a leading global contract research organization and world leader in serving science. We are passionate, deliberate, and driven by our mission - to enable our customers to make the world healthier, safer, and cleaner.

Within our Analytical Services team, we have a functional service provider solution, which is a unique partnership that allows our customers to leverage the experience of our staff, while allowing you, the employee, to gain direct experience working onsite at a pharmaceutical/ biopharmaceutical company, all while maintaining full-time benefits.

Job Responsibilities:

Task 1: Support lead scientist to deliver top candidates of site-specific integration (SSI) platform in the Client's Vx CHO cells through a genome-wide screening approach
Deliverables:
a. Design and synthesis (outsourcing) of necessary constructs
b. Production of stable pools and clones
c. Screening for clones with target profile (stability and productivity)

Task 2: Support lead scientist to reverse-engineer pre-existing high-producing CHO clones into PoC SSI candidates
Deliverables:
a. Design and synthesis (outsourcing) of necessary constructs
b. Production of engineered CHO clones
c. Screening for clones with targeted insertion profile

Preferred Qualifications:

• Excellent communication skills and ability to effectively collaborate within multiple project workstreams
• Critical thinking skills and ability to efficiently manage changes in priorities and timelines
• Attention to detail and meticulous execution of project-related tasks
• Plasmid and viral vector cloning, qPCR/ ddPCR, wet lab next-generation sequencing (NGS)
• Experience with FACS analyser/single cell sorter
• Experience with CRISPR or other genomic editing tools
• Applies detailed fundamental knowledge of own specialty area or scientific discipline into solving process development problems

- Experience with Mammalian Cell Culture

• Identifies and prioritizes solutions using knowledge gained through formal education, experience, and sound judgment
• Fully understands the rationale and hypotheses for experimental designs

Education and Experience:

Bachelor's degree in molecular biology, cell biology, virology, or other vaccinology-related discipline or equivalent and relevant formal academic / vocational qualification

Previous experience that provides the knowledge, skills, and abilities to perform the job (comparable to 4+ years).

In some cases, an equivalency, consisting of a combination of appropriate education, training and/or directly related experience, will be considered sufficient for an individual to meet the requirements of the role.

Knowledge, Skills and Abilities:

• Proficient in Microsoft Excel and Word
  
• Relevant research and development experience in an industrial, academic, or government laboratory setting
  
• Hands-on experience with aseptic small scale (plate- to shake flask-based) mammalian cell culture (thawing, expanding, freezing), transfection techniques, and clonal isolation
  
• Hands-on experience with common nucleic acid- and protein-based in-process analytic assays (e.g., PCR, RTPCR, ELISA, SDS-PAGE, Western blot)
  
• Experience with mammalian cell culture is preferred
  
• Fluency in English
  
• Proven ability to interpret data by performing trend analysis
  
• Proven ability in technical writing skills
  
• Ability to independently optimize analytical methods
  
• Proven problem solving and troubleshooting abilities
  
• Good written and oral communication skills
  
• Time management and project management skills
  
• Ability to work in a collaborative work environment with a team
  

• PPD values the health and well being of our employees. We support and encourage individuals to create a healthy and balanced environment where they can thrive. Below is listed the working environment/requirements for this role:
• Able to communicate, receive, and understand information and ideaswith diverse groups of peoplein a comprehensible and reasonable manner.
• Ableto work upright and stationary and/or standingfor typical working hours.
• Able to lift and move objects up to 25 pounds
• Able to work in non-traditional work environments.
• Able to use and learn standard office equipment and technologywith proficiency.
• May have exposure to potentially hazardous elements, including infectious agents, typically found in healthcare or laboratory environments.
• Able to perform successfully under pressure while prioritizing and handling multiple projects or activities.