Senior Scientist, Oncology Safety Science
AstraZeneca

Job Title: Associate Director, Oncology Safety Science

Introduction to role:
We are seeking a highly motivated Associate Director to support the development of novel oncology medicines with a focus on T Cell Engagers for haem and solid tumor indications. This role will support investigative toxicology for project progression and drive our safety science forward to inform the design and selection of drug candidates with the "right safety" profile. An established record of safety science in an academic or industry setting with experience of the application of in vitro and/or in vivo models is essential. This position will report to the Senior Director of Oncology Safety Science. The group supports early safety assessment of T Cell Engagers, Immuno-Oncology Therapeutics, Cell Therapies. We are based in Cambridge UK, Gaithersburg MD, and Boston MA.

Accountabilities:
As a core member of multi-disciplinary drug discovery teams, you will direct investigative toxicology strategies to predict, assess and mitigate target- and modality-related safety risks in discovery programs, with a focus on T Cell Engagers. You will apply investigational and mechanistic safety studies through in vitro experimental capabilities to predict clinical safety and inform decision-making in drug discovery and development programs. You will contribute to early oncology project decision making, address specific concerns, and present findings to ensure that teams can make the right decisions regarding safety risks that facilitate timelines and regulatory submissions. You will maintain expertise in regulatory requirements and preclinical safety approaches applied to Immuno-Oncology therapeutics and awareness of industry trends. You will develop and influence the adoption of innovative solutions and research proposals to pursue cutting edge science and technologies in line with business needs versus safety. You will publish in high quality, peer-reviewed journals, present at internal scientific meetings and external conferences.

Essential Skills/Experience:
• PhD in immunology, cancer biology, cell biology, toxicology, pharmacology, or related field with experience preferably in industry or academic setting with a minimum of 3 years' experience.
• A proven understanding of drug discovery and development, with a strong scientific track record with experience of independent research in industry, biotech, or academic setting, working with relevant T Cell Engagers.
• Experience with in vitro cellular biology/immunology assays applied to physiologically relevant human cellular models, flow cytometry, multiplex cytokine measurements, activation and cytotoxicity assays, micro-physiological systems, 3D organoids, membrane protein arrays, omics technologies, confocal imaging.
• Experience with the design and execution of in vivo studies to determine the effects of T Cell Engagers on biological systems with line of sight to human safety may be considered an advantage.
• The ability to build an understanding of biology around novel drug targets and pathways, develop testable hypotheses, and drive scientific learning.

Desirable Skills/Experience:
• A collaborative, team-oriented approach, able to solve problems in a goal-focused fashion with capacity to coordinate tasks across multiple projects.
• Excellent communication, presentation, interpersonal and influencing skills across levels/subject areas with a strong desire to drive personal development within an industry setting.

When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.

Why AstraZeneca?
Join the team unlocking the power of what science can do. We are working towards treating, preventing, modifying and even curing some of the world's most complex diseases. Here we have the potential to grow our pipeline and positively impact the lives of billions of patients around the world. It's our combination of curiosity and courage that drives us, inspired by the possibility of doing things that have never been done before. Empowered to step up, we free ourselves from fear of failure to dig deep into the biology of complex diseases and make bold decisions. Celebrating our successes and failures along the way.

Are you ready to make a difference? Apply now and join us in our journey to push the boundaries of science and deliver life-changing medicines!

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.