Senior Scientist, Oncology Safety Science
AstraZeneca

Job Title: Senior Scientist, Oncology Safety Science

Introduction to role:
Are you ready to contribute to the discovery of novel oncology medicines? We are seeking a highly motivated Senior Scientist to join our team. This role will design and execute experimental strategies to enhance our investigative toxicology capabilities and drive our safety science forward. You will be able to develop your knowledge and skills by working together with experts and leaders in Oncology R&D, safety science, pharmacology, toxicology, drug discovery and development, imaging, pathology, and translational science. This position will report to the Senior Director of Oncology Safety Science. We are based in Cambridge UK, Gaithersburg MD, and Boston MA.

Accountabilities:
As a Senior Scientist, you will design and execute experimental strategies to predict, assess and mitigate target- and modality-related safety risks in discovery programs. You will perform investigational and mechanistic safety studies through in vitro experimental capabilities to predict clinical safety and inform decision-making in drug discovery and development programs. You will also contribute to early oncology project safety assessment, address specific concerns, and present findings to ensure that teams can make the right decisions regarding safety risks.

Essential Skills/Experience:
• PhD in immunology, cancer biology, cell biology, toxicology, pharmacology, or related field with experience preferably in industry or academic setting.
• A strong scientific track record with experience of independent research in industry, biotech, or academic setting, working with T Cell Engagers or relevant immunotherapies.
• Experience with in vitro cellular biology/immunology assays applied to physiologically relevant human cellular models, flow cytometry, multiplex cytokine measurements, activation and cytotoxicity assays, micro-physiological systems, 3D organoids, membrane protein arrays, omics technologies, confocal imaging.
• Experience with the design and execution of in vivo studies to determine the effects of T Cell Engagers on biological systems with line of sight to human safety may be considered an advantage.
• The ability to build an understanding of biology around novel drug targets and pathways, develop testable hypotheses, and drive scientific learning.

Desirable Skills/Experience:
• A collaborative, team-oriented approach, able to solve problems in a goal-focused fashion with capacity to coordinate tasks across multiple projects.
• Excellent communication, presentation, interpersonal and influencing skills across levels/subject areas with a strong desire to drive personal development within an industry setting.

When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.

Why AstraZeneca?
At AstraZeneca's Biopharmaceuticals R&D division, we follow the science to explore and innovate. We are working towards treating, preventing, modifying and even curing some of the world's most complex diseases. Here we have the potential to grow our pipeline and positively impact the lives of billions of patients around the world. We are committed to making a difference and have built our business around our passion for science. Now we are fusing data and technology with the latest scientific innovations to achieve the next wave of breakthroughs.

Join us and be part of a team that makes a bigger impact on patients' lives. Here we truly understand science and apply it every day to strengthen and grow our pipeline. We are using our unique scientific capabilities to deliver what we believe to be one of the most productive pipelines in the industry. There's great potential too with lots of different indications.

Ready to make a difference? Apply today!

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.